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2023 American Academy of Allergy, Asthma & Immunology. Although any drug can cause an allergic reaction, some drugs are more commonly associated with allergies. Drugs can also interact with each other, with foods, or with supplements. Had the reaction within one hour of taking penicillin, Developed raised and itchy skin patches (hives), Had swelling of your face, throat, hands or feet (angioedema), Had wheezing, chest tightness or difficulty breathing. Medically reviewed by Sally Chao, MD. Depending on the type of penicillin, common side effects may include mild nausea or diarrhea, headache, or vaginal itching. When this coupling is inhibited, transpeptidation reaction is stopped between amino acids and protein chains are not synthesized. Sulfonamides and trimethoprim are antimetabolites selectively toxic to microorganisms because they interfere with folic acid synthesis. Ciprofloxacin can cause serious side effects, including tendon problems, damage to your nerves (which may be permanent), serious mood or behavior changes (after just one dose), or low blood sugar (which can lead to coma). An allergist / immunologist can perform this testing, and if it is negative, there is a very high chance that the allergy is no longer present. Who Is The Father Of Jodie Fosters Baby? Penicillin allergy is more likely to occur in those people suffering from allergy conditions like urticaria and asthma. Salicylate Allergy Symptoms. This will come in handy in cases where you are unconscious or seriously injured. Ut wisi enim ad, Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh. In addition to drug side effects, drug toxicity can occur when too much of a drug is in a persons body (can be unintentional or intentional). If a person is experiencing any symptoms of anaphylaxis, it is important to follow your emergency plan, administer epinephrine (if available) and seek emergency care. You may also want to wear a penicillin allergy alert bracelet. It is possible to be allergic to the drug and still be able to eat the cheese with impunity, although there are also people who are allergic to both. No interactions were found between penicillin / procaine penicillin and Tylenol. Sulfa can be found in many different drugs, but sulfonamide antibiotics cause the majority of sulfa allergies. Can I eat blue cheese if Im allergic to penicillin? Doctors most often prescribe penicillin or amoxicillin (Amoxil) to treat strep throat. This site uses cookies. gentamicin) and glycopeptides (e.g. Cephalosporin use in penicillin-allergic patients Many cephalosporins, especially in the later generations, can be safely tolerated despite a penicillin allergy. In particular, this supplement is used for osteoarthritis, according to Medline Plus. The process is simple. Penicillins belong to a class of drug called beta lactams because they contain a special beta lactam ring in their structure that is considered to be responsible for its anti microbial activity. The answer to this is somewhat dependent on the type of reaction you experienced. Antistaphylococcal penicillins (cloxacillin, dicloxacillin, nafcillin, and oxacillin) Broad-spectrum penicillins (carbenicillin, mezlocillin, piperacillin, ticarcillin) Beta-lactamase inhibitor (clavulanic acid) Each of these types has a slightly different molecular structure and may be administered differently than the others. 8. They are rare, but they include these syndromes: If you have had any signs of a penicillin allergy, or if you suspect a penicillin allergy for any other reason, talk to your doctor before you need an antibiotic. However, if youve been told you have a penicillin allergy by a doctor who is not an allergist, you may want to confirm the diagnosis. An allergic reaction to penicillin in childhood does not automatically predict a reaction as an adult. Most people lose their penicillin allergy over time, even patients with a history of severe reaction such as anaphylaxis. Once the bacteria lose their cell wall, they begin to die rapidly. A penicillin allergy is one of the most commonly reported drug allergies. Today, the family of penicillin drugs includes more than 15 different antibiotics, such as: Penicillin Ampicillin Amoxicillin Methicillin. By continuing to browse this site, you are agreeing to our use of cookies. Here are the groups of protein synthesis inhibitors: Fluoroquinolones are a separate group of drugs with a very wide spectrum of antibiotic activity. Penicillin binds to specific enzymes located in the cell wall of bacterial cells, known as penicillin binding proteins. Amoxicillin rash: When should I be concerned? Common signs and symptoms of penicillin allergy include hives, rash and itching. griseofulvum is frequently isolated from corn, wheat, barley, flour, and walnuts (40) and from meat products (27), thus being a potential source for the presence of penicillin in food. Drug rash with eosinophilia and systemic syndrome (DRESS). A total of 36 drugs are known to interact with Penicillin VK . There are also many broad-spectrum antibiotics that can be used in place of penicillin. Stay in the Know with News in Your Mailbox, 2023 Allergy & Asthma Network | All Rights Reserved. If you don't have a skin reaction to penicillin, there is a 95 percent chance you are not allergic. prevention of Mycobacterium avium complex disease. If it was an ADR, consider whether the . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Sulfacetamide (BLEPH-10), drops for eye infections. INTRODUCTION. If we combine this information with your protected The milk is tested for at least four of six beta-lactams, such as penicillin and amoxicillin. If you suspect an allergy to penicillin, it is recommended that you take an allergy test to determine the types of penicillin to which you are allergic. Beta lactamase producing bacteria cane be killed by adding inhibitors of beta lactamases like clavulanic acid, sulbactam and tazobactam to penicillin antibiotics. Penicillin is prescribed for treating various bacterial infections. Aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. For emergency purposes, it is wise to wear a bracelet that states your allergies. Penicillin allergy occurs when the bodys immune system shows overreacted response against penicillin antibiotics. Serious allergic reactions can occur in some people who take Augmentin. It is a penicillin type antibiotic and it does not have sulfa in it. clarithromycin), aminoglycosides (e.g. This was the case in six of the twelve serendipitous discoveries reviewed in this paper, i.e., aniline purple, penicillin, lysergic acid diethylamide, meprobamate, chlorpromazine, and imipramine. See your doctor as soon as possible if you experience signs or symptoms of penicillin allergy. There is a plausible causal relationship between J&J/Janssen COVID-19 Vaccine and a rare and serious adverse eventblood clots with low platelets (thrombosis with thrombocytopenia syndrome, or TTS). Tetracyclines (e.g. Dont wait until youre in a medical emergency. A lot of people are diagnosed with a penicillin allergy in childhood, but many of these allergies are very mild. If you think you have a penicillin allergy, chances are you probably don't. Save my name, email, and website in this browser for the next time I comment. No, you should not take amoxicillin if you are allergic to penicillin. Theyre actually in the same family of antibiotics, called the penicillin family. Intradermal skin testing is the second part of the evaluation and involves injecting the skin. These drugs belong to different drug classes. Having a true allergy to penicillin is serious. What should I avoid while taking ciprofloxacin? Common allergic reactions to penicillin include rashes, hives, itchy eyes, and swollen lips, tongue, or face. Thus, all above mechanism are responsible for making bacteria resistant to penicillin action. Penicillins are the bactericidal drugs that inhibit the cell wall synthesis in bacterial cells. By using this site you agree. Many of these reactions when fully assessed have been found not to be anaphylaxis, or caused by triggers other than sulfites. Allergy to penicillin and alternative antibiotics, See numbered references within the article, Difficulty in breathing and chest tightness, Cold clammy skin or blue discoloration of skin. Therefore, an accurate diagnosis is needed when penicillin allergy is suspected to ensure the best treatment options in the future. Tetracyclines (e.g. Accessed Oct. 24, 2019. From a regulatory perspective, the TGA has reviewed all the available evidence and determined that the AstraZeneca vaccine can be safely administered 4-12 weeks apart. Prednisone vs Prednisolone - What's the difference? All bacteria need a shielding cell wall for their survival in the body. A single copy of these materials may be reprinted for noncommercial personal use only. Based on these factors, you and your doctor can decide whether you should have testing for a penicillin allergy. In general, you should avoid the following medications if you have a sulfa allergy: One important exception is sulfasalazine (Azulfidine). So, in order to establish the diagnosis of penicillin allergy, skin allergy test should be done on patients who complain of allergy to penicillin. No interactions were found between ibuprofen and Penicillin VK. Call 911 and go to the emergency department immediately. Penicillins belong to a class of antibacterial drugs called beta-lactam antibiotics. What can I take if im allergic to penicillin? 11. 2. Many people experience constipation with narcotic medications. Experiencing an allergic reaction to a sulfonamide antibiotic does not mean that you will react poorly to sulfonamide nonantibiotic drugs. Glucosamine sulfate is a dietary supplement used as a complementary therapy for arthritis. Most hospitals or clinics have access to an allergist / immunologist who can help facilitate this. Corticosteroids. Can people with allergies take the Covid vaccine? Examples of reactions not involving the immune system include: The impact of a reaction to medication can range from annoying to severe. Can I take Augmentin if Im allergic to penicillin? Pediatric patients This will allow you to be treated safely with a large penicillin dose. The American College of Allergy, Asthma and Immunology lists the following antibiotics as ones to avoid if you have a penicillin allergy: Amoxicillin Ampicillin Dicloxacillin Nafcillin Oxacillin Penicillin G Penicillin V Piperacillin Ticarcillin Cefaclor Cefadroxil Cefazolin Cefdinir Cefotetan Cefprozil Cefuroxime Cephalexin (Keflex) Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Increased exposure to penicillin, because of high doses, repetitive use or prolonged use; Certain illnesses commonly associated with allergic drug reactions, such as infection with HIV or the Epstein-Barr virus; Prevention. Not all bacterial infections are treated with penicillin, but if you have an infection that is usually treated by penicillin, you may be able to take a drug that is similar to penicillin called a cephalosporin. Peanut oil is found in certain prescription drugs and OTC medicines. Since the 1940s, penicillin has been a go-to drug. There are also many broad-spectrum antibiotics that can be used in place of penicillin. Is there penicillin in the Covid vaccine Johnson and Johnson? Stopping the bacterial DNA replications means the bacterial cells will no longer be able to multiply or divide now, because DNA replication is necessary for cell division and bacterial growth. Severe reactions include anaphylaxis, a life-threatening condition that affects multiple body systems. Therefore, the risk of developing a severe allergic reaction is very low. A raised wheal at the site of the prick indicates allergy. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If you develop flushing or hives within a few hours of taking a medication, call a board-certified allergist. Visit our Penicillin Allergy Center. Not every reaction to a medication is a drug allergy. What Antibiotics can I take if allergic to penicillin and sulfa? Can I eat blue cheese if Im allergic to penicillin? https://www.merckmanuals.com/professional/immunology-allergic-disorders/allergic,-autoimmune,-and-other-hypersensitivity-disorders/anaphylaxis?query=anaphylaxis. Penicillin is prescribed for treating various bacterial infections. This content does not have an Arabic version. For more serious problems such as swelling, they might give you a medicine called a corticosteroid. (February 10, 2019). Proteins act as the main control system of bacteria cells. These drugs are also more likely to cause antibiotic resistance and result in an infection that is very hard to treat. Fluoroquinolones are effective against gram positive cocci (streptococcus pneumonia), gram positive rods (Bacillus anthracis) and gram negative rods (Enterobacter species, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Legionella, Proteus, Pseudomonas aeruginosa, chlamydia, Mycoplasma, serratia and shigella species. In other cases, a person may report a family history of penicillin allergy, but penicillin allergy is not passed down through families. However, molecular traces of these proteins may be present in fish oil, and there is a chance you could have an allergic reaction to fish oil if you are allergic to shellfish. They may prescribe a medicine called an antihistamine, such as diphenhydramine, to help with your symptoms. Medications can also produce side effects, which again, arent allergies. Some allergic reactions to drugs - particularly rashes, hives and asthma - can resemble certain diseases. In people who are prone to penicillin allergy, their immune system considers penicillin as an intruder or harmful substance and launches an immune reaction against it. What will happen during my visit with the allergist / immunologist? Fish oil does not contain protein from shellfish flesh, which typically triggers the shellfish allergic reaction. However, the choice of alternative antibiotic depends upon the kind of infection that needs to be treated. People can have various adverse reactions to drugs or medications, but most of these are not allergic reactions. Severe reactions include anaphylaxis, a life-threatening condition that affects multiple body systems. Signs and symptoms of penicillin allergy often occur within an hour after taking the drug. Allergic to Penicillin? A skin prick test, also called a scratch test, checks for immediate allergy and is the first step in skin testing. It is one of the most frequently used classes of antibiotics in the world. Over 95 percent of people with penicillin allergy can safely take cephalosporins, which are a bit structurally different from penicillins. Has anyone had an anaphylactic reaction to the J&J Covid vaccine? The researchers estimated that both skin tests and blood tests give negative results in more than 95% of individuals who do not have a true penicillin allergy. Cephalosporins can be prescribed safely for penicillin-allergic patients. Accessed Oct. 24, 2019. Tests and case studies for medical students. swelling of the mouth or throat. Fluoroquinolones enter the bacterial cells either through passive diffusion or through special channels called porins. Parent-Reported Penicillin Allergy Symptoms in the Pediatric Emergency Department. ciprofloxacin), macrolides (e.g. Sulfadiazine silver (Silvadene), a cream to prevent and treat burn infections. The test, if positive, will cause local itching and redness with swelling at the site where the test is performed. A positive skin test is an indicative of penicillin allergy. Sustanon is an injectable form of testosterone used as hormone replacement therapy for men with low testosterone. Penicillin What Is a Penicillin Allergy? What are the most common side effects of penicillin? How can I tell if Im allergic to penicillin? These antibiotics can be given by mouth or injection to treat many types of bacterial infections. Some of the common signs and symptoms of penicillin allergy are: Anaphylaxis is described as an allergic reaction that involves all the organs of the body and proves to be a fatal condition. Other antibiotics, particularly those with chemical properties similar to penicillin, also can result in allergic reactions. The Pfizer and AstraZeneca COVID-19 vaccines do not contain penicillin or any other antibiotics. However, even with treatment, the signs and symptoms of an allergic reaction to penicillin can last anywhere from 2 to 4 weeks. American College of Allergy, Asthma & Immunology. Antivirals, such as amprenavir and fosamprenavir, Carbonic anhydrase inhibitors, such as acetazolamide and brinzolamide, COX-2 inhibitors, such as celecoxib and rofecoxib, Loop diuretics, such as bumetanide and furosemide, Sulfonylureas, such as acetohexamide and chlorpropamide, Thiazide diuretics, such as benzthiazide and chlorothiazide, Triptans, such as almotriptan and eletriptan. Official Answer. How long does it take for a boil to heal while taking Bactrim? https://www.uptodate.com/contents/search. Do I need to avoid other drugs if I am allergic to penicillin? Drug toxicity can show up in a variety of different ways and can even lead to death in extreme cases. You do not need to avoid penicillin if a family member is allergic to penicillin or drugs in the penicillin family. You may be sent to an allergist for testing. Read more: Could I be allergic to water? Clostridioides difficile Infection. Do not take this medication if you are allergic to cefaclor, or to similar antibiotics, such as Ceftin, Cefzil, Duricef, Fortaz, Keflex, Omnicef, Spectracef, Suprax, and others. In an article from Journal of Advanced Pharmaceutical Technology and Research, symptoms of penicillin allergy are classified into three categories: common adverse reactions, infrequent adverse effects, and true anaphylaxis. clarithromycin), aminoglycosides (e.g. Name of Drug Dosage, Route, Mechanism of Action Indication Adverse Reactions Special Precautions Nursing Responsibilities Frequency and Timing Generic: Hemarate contains iron, Prevention and treatment Hypersensitivity Lactation: Observe 12 rights of drug Multivitamins Dosage: 320 mg and vitamins B6 and B12 of iron deficiency reactions: hives . Tightening of the airways and throat, causing trouble breathing, A history of other allergies, such as food allergy or hay fever, Increased exposure to penicillin, because of high doses, repetitive use or prolonged use, Certain illnesses commonly associated with allergic drug reactions, such as infection with. Fluoroquinolones are divided into four generation depending upon the slight variation in their antibiotic spectrum. By eating a few cloves of garlic each day, you can effectively fight off all sorts of bacteria, viruses and infections. Examples are resistant staphylococci and gram negative bacteria. Clindamycin will not work for colds, flu, or other virus infections. INTRODUCTION. Thus, the diagnosis of penicillin allergy cannot be made alone on the basis of signs and symptoms because mild allergic reactions often mimic the side effects of drug. Are you among the 10% of the population who report having a penicillin allergy? Since the discovery and development of penicillin G, the first type of penicillin, several other types have been developed, including penicillin V, procaine penicillin and benzathine penicillin. light-headedness. We use cookies for various purposes including analytics and personalized marketing. Those who are allergic to one penicillin antibiotic for example penicillin G, they also show hypersensitivity to other penicillin drugs as well. What to know when we add a new business or post? ciprofloxacin), macrolides (e.g. Depending on the type of penicillin, common side effects may include mild nausea or diarrhea, headache, or vaginal itching. It's important to understand and discuss what is an allergic reaction, what is a typical side effect and what you can tolerate in taking a medication. Select one or more newsletters to continue. the unsubscribe link in the e-mail. Serendipity in drug discovery implies the finding of one thing while looking for something else. Zithromax is not a penicillin it is a type of antibiotic called a macrolide. P. griseofulvum is frequently isolated from corn, wheat, barley, flour, and walnuts (40) and from meat products (27), thus being a potential source for the presence of penicillin in food. skin infection due to Staphylococcus aureus bacteria. (March 24, 2019). Some evidence suggests that trace amounts of it in the food supply may be sufficient for a person's immune system to create an antibody to it. The chances of cross reactivity between penicillins and antibiotics of other groups are rare. If and when your immune system misidentifies penicillin as a harmful substance, it develops an antibody to the drug. Both drug are used to treat bacterial infections such as urinary tract infections, bronchitis and other lung infections. Reactions can include hives, swelling, cough, wheezing and difficulty breathing. Acad Pediatr. All protein synthesis inhibitors bind to 50S ribosomal unit, except for tetracyclines which bind to 30S unit, and inhibit the coupling of m-RNA and t-RNA. Having an infection such as human immunodeficiency virus (HIV) or Epstein-Barr virus, which can contribute to allergic drug reactions Modern-day penicillin antibiotics are produced synthetically and are not contaminated with mold particles. Albuterol Sulfate belongs to a class of drugs called bronchodilators. 2019; doi:10.1001/jama.2018.19283. Penicillins need to be avoided and a different antibiotic will be needed to treat infections. Can you take Tylenol if you are allergic to penicillin? Which Is More Stable Thiophene Or Pyridine? These structurally altered proteins have less affinity for penicillin that affords resistance to bacteria. Common signs and symptoms of penicillin allergy include hives, rash and itching. Anaphylaxis. For instance, you may be allergic to amoxicillin and oxacillin but not to penicillin G. Certain factors can increase the likelihood of developing an allergy to penicillin such as heredity, other allergies such as food or pollen allergy, other drug allergy and aggressive illnesses that combat the effects of penicillin such as HIV. Penicillin Allergy what do you need to know? When this happens, the microorganism is rendered vulnerable to osmotic pressure and thus, bursts and dies. Will Windshield Replacement Raise My Insurance. Allegra vs Zyrtec: What's the difference? Signs and symptoms of penicillin allergy vary from mild skin rashes to severe anaphylactic shock. Amoxicillin is able to get rid of a broader range of bacteria compared to penicillin. Home | About | Contact | Copyright | Privacy | Cookie Policy | Terms & Conditions | Sitemap. Tetracyclines (e.g. 5,6 These reactions usually appear as urticaria, angioedema . Anyone who is allergic to one type of penicillin should be considered allergic to all penicillin and should avoid the entire medication group. This leads to misdiagnosis and use of inappropriate antibiotics for treating patients condition that are less effective. Which antibiotics can you take? Available for Android and iOS devices. One study reported in a review in Canadian Family Physician found that penicillin, which is substantially different from sulfa antibiotics, was more likely to cause an allergic reaction than sulfa nonantibiotics among people allergic to sulfa antibiotics. Bactrim (sulfamethoxazole and trimethoprim) is a combination of two antibiotics (a sulfa drug and a folic acid inhibitor) and Cipro (ciprofloxacin) is a quinolone antibiotic. Sometimes, a common reaction to penicillin (such as an upset stomach or diarrhea) is mistaken for an allergy. gentamicin) and glycopeptides (e.g. It occurs at a rate of about 7 per 1 million vaccinated women between 18 and 49 years old. 2018; doi:10.1016/j.mayocp.2017.09.020. If symptoms are severe, the first line of treatment is epinephrine. Tingling or itching in your mouth. Remember that many medicines may look or sound alike, so dont assume a doctor is always able to correctly identify it based on a description. Skin testing at a doctor's office is the best way to find out for sure whether you are allergic to penicillin. Before the immune system can become sensitive to penicillin, you have to be exposed to the medication at least once. See the CDC issued guidance for people with allergies. However, Medline Plus indicates shellfish allergies are usually based on the meat of shellfish rather than the shell, and many people with shellfish allergies can take glucosamine sulfate without adverse reactions. By giving amoxicillin to patients with a history of reported mild reactions to penicillin, Dr. Jerschow demonstrated that 97% of patients could safely receive penicillin again. However, it is rare condition and occur only ij few atients. Common signs and symptoms of penicillin allergy include hives, rash and itching. It typically takes about 2 to 3 hours to perform all of the testing. What are the effects of taking expired benadryl? Can You Outgrow a Penicillin Allergy? When folic acid synthesis is inhibited, DNA replication will be reduced and bacterial cells will stop dividing. If you have a history of immediate onset anaphylaxis to multiple classes of drugs or unexplained anaphylaxis please also refer to the additional information at the end of these FAQs. Can I take doxycycline if I am allergic to penicillin? Penicillin medications include: Amoxicillin Ampicillin Dicloxacillin Penicillin G Penicillin V Nafcillin Piperacillin Oxacillin Ticarcillin These infections are both serious and hard to treat. What is the Best Way to Clean a BBQ Grill? Signs or symptoms of an infection for which you are being treated or unrelated symptoms also may be mistaken as an allergic drug reaction. Examples of sulfonamides includes sulfadiazine, sulfamethizole (brand name: Thiosulfil Forte), sulfamethoxazole (Gantanol), sulfasalazine (Azulfidine), sulfisoxazole (Gantrisin), and various high-strength combinations of three sulfonamides. People can be allergic to certain vaccines. Nasal Allergy, Rhinitis and Allergic Rhinitis, Managing Asthma in School: A Guide for Parents, Managing Allergies at School: A Guide for Parents, Managing Allergies at School: A Guide for School Staff. Accessed Oct. 22, 2019. Mile allergic reactions can be controlled well with the help of antihistamine drugs but, anaphylaxis is a medical emergency that needs to be corrected through epinephrine injections. If you don't have a reaction to the oral challenge or the skin testing, there is almost a 100 percent chance you are not allergic. Not all bacterial infections are treated with penicillin, but if you have an infection that is usually treated by penicillin, you may be able to take a drug that is similar to penicillin called a cephalosporin. You may not be able to take this medication again if youve ever had a serious allergic reaction to it. The American College of Allergy, Asthma and Immunology reports that penicillin causes most allergic drug symptoms. blistering, peeling, or loosening of the skin. Which Is More Stable Thiophene Or Pyridine? This type of reaction usually happens within an hour after you take penicillin. Skin prick testing uses needles (lancets) that barely penetrate the skin's surface. health information, we will treat all of that information as protected health The decision of whether you need to carry an epinephrine autoinjector should be made after specialty consultation with your allergist / immunologist. Penicillin allergy signs and symptoms may include: Anaphylaxis is a rare, life-threatening allergic reaction that causes the widespread dysfunction of body systems. Last updated on July 5, 2021. Penicillin allergy signs and symptoms may include: Official Answer. What do they prescribe if you are allergic to penicillin? There are a number of cephalosporin medications available, including cephalexin (brand name: Keflex), cefaclor (brand name: Ceclor), cefuroxime (brand name: Ceftin), cefadroxil (brand name: Duricef), cefprozil (brand name: Cefzil), ceftibuten (brand name: Cedax), cefdinir (brand name: Omnicef), cefpodoxime, and cefixime (brand name: Suprax). Sometimes penicillin is the best drug to treat a certain infection. 3. This ultimately ends up in initiation of allergic reactions (1). Call 911 or emergency medical help if you experience signs of a severe reaction or suspected anaphylaxis after taking penicillin.