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[4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. Privacy Policy. Modern Medicine, Part I: How Healing Illness Becam Is your body getting too acidic? I discovered this article published in Wakeup World. 2002 Feb ;25(2):106-9. Another recently approved drug is tepotinib (Tepmetko). As a person with Graves Disease, I underwent 6 cycles of radio-ablation using i 131 to 'fry' my thyroid gland as surgery was deemed too risky due to the vascularity and size of my gland. At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. Share your experience, learn from others. I hope that with increased knowledge we will all find the right road. The great open sky of imagination: for those who u Fermented Foods: Top 8 Reasons to Eat Them. View the data on GreenMedInfos Hypothyroidism Research page. The Remarkable Heart-Friendy Properties of Avocados. [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. However, the study looked at the incrase of ALL lung cancers, not SCLC, so that data does not correlate with this study. [3]Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. Hashimoto's disease progresses slowly over the years. For a better experience, please enable JavaScript in your browser before proceeding. The authors expanded on their findings further: However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. Different strokes for different folks for sure! This is a news report of the research, so I can't learn the details of how the science was conducted. 2004 Jun;9(2):157-79. Once I got on the medication, the symptoms disappeared. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. Now, I will bring it to the attention of my Endocrinologist. This relatively symptom-free reservoir of 'hypothyroid' cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Posted on: Monday, August 12th 2013 at 7:15 am Written By: Sayer Ji, Founder A new study has. Cookie Notice They also noted that oxidative stress is one of the causes of chronic diseases and cancer. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called 'subclinical' hypothyroidism only detected via blood work. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. I wonder if only t3 treatments are preferable than t4 and t3 ? At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer This discussion has been closed to comments. Endocrinology 1985, 117:12011208. Compression of the trachea, which may be positional, can occur with nodular goiters and thyroid cancer, and the latter can metastasize to the lungs. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. I very much appreciate the information you shared. Is Drug-Based Medicine a Form of Human Sacrifice? In 2011 I switched docs and was put on Armour as he told me Synthroid and the like are poison and they do not work. radioactive treatments. I am having a lot of trouble making any sense of this study. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low . Ultimately, this Italian study brings further attention to one of a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. In comparison, 62.4% of female and 37% of male . "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)". With the recent announcement by a National Cancer Institute commissioned expert panel that a variety of so-called 'indolent' neoplasms such as ductal carcinoma in situ (DCIS) and high-grade prostatic intraepithelial neoplasia (HGPIN), formerly understood to be forms of breast and prostate cancers, respectively, should be renamed to reflect their intrinsic benignity, a veritable sea change is occurring within the conventional medical establishment. J Endocrinol Invest. Post by D.ap Tue Feb 21, 2017 6:40 pm "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and . [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. hyperthyroidism. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5-monodeiodination (DI). (31) 3351-3382 | 3351-3272 | 3351-3141 | 3351-3371. location of blind frog ranch associe-se. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. In the United States, autoimmune thyroid disease (Hashimoto thyroiditis) is the most common cause of hypothyroidism, but globally lack of iodine in the diet is the most common cause. Is that what releases free radicals? undefined will no longer be visible to you including posts, replies, and photos. Or, simply look at what the young-adult,T-score based definition of osteoporosis and osteopeniahas done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. elevated TSH, without actually improving the overall physiological situation, nor the patient's subjective experience of well being. But I for one, do appreciate anything that other members forward about potential links, causes, aids to healing, whatever you can them. [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. Non-small cell lung cancer is the most common type of lung cancer, accounting for about 81% of all cases. As a never smoker I truly wish I smoked so I could just say that's why I got this. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. Increased sleepiness. Here members can share stories, find important information and learn from the experiences of others like themselves. Correlation is when two things seem to happen at the same time, in the same place, and/or in the same population. Even in the mildest form, hypothyroidism affects the heart. It is very tormenting (for me anyhow) to not know why I got this disease. This relatively symptom-free reservoir of hypothyroid cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. [3] Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). I don't believe there are thousands of people on to high a dose of t4, so why does it feel they are hyper? I think part of sharing information here on Inspire is the discussions about the articles we share. Could be another marmalade how would we know? Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. I cried with joy when I found out there was something really wrong with me. Keep checking back for the register link to appear. Compared to patients without hypothyroidism, those with a high TSH level before hospitalization stayed in the hospital 1.2 days longer and had a 49% higher risk of 30-day readmission and a 43% . It looks at correlations, as if they had any merit on their own. Article published in Wakeup-World.Com. Tokushima J Exp Med 1991, 38:2535. Join the Patient & Caregiver Network. ", That study is like a fishing expedition. Join the forum, it's quick and easy . The estimated 2.3 million new cases indicate that 1 in every 8 cancers diagnosed in . Patient characteristics. Intuition and Trust: a Personal Journey Through Ancient Pathways, Meditation, Yoga, Grounding & Mindfulness, Levothyroxine and lung cancer in females: the importance of oxidative stress, 2013 announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs, Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. [5] Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5' deiodinase in lung cancer with peripheral lung tissues. Other factors that can trigger thyroid problems include: autoimmune diseases like Hashimoto's or Graves' disease; thyroid surgery; radiation treatments to the neck or upper chest; and certain medications, including interferon alpha and interleukin-2 cancer medications, amiodarone . In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to 'replacement' therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. Sub-laboratory hypothyroidism and the empirical use of Armour thyroid. Angiology 2000, 51:S65S68. I have sent the link that I read today. Hypothyroidism reduces respiratory drive and can cause obstructive sleep apnea or pleural effusion, while hyperthyroidism increases respiratory drive and can cause dyspnea on exertion. I will respond more later onBut I will briefly say I was on Synthyroid from 1993 to 2011. You must log in or register to reply here. The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. [14] In other words, you can normalize the main clinically measurable parameter associated with low thyroid function, i.e. I invite those interested to read it and perhaps we can have a discussion on this study. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. Cancer-related fatigue (CRF) is common in lung cancer survivors and can occur at any point in the care continuum. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called active ingredient T4 versus the natural variations in hormone concentrations found in the real thing, which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. Clin Cancer Res 2011, 30:77. Assessment of oxidative stress and its balance has not been taken into consideration up to now as it should be. BUT, this is the first I have heard of the potential risk of lung cancer in those who take Synthyroid. 500+ pages of Natural Medicine Alternatives and Information. 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Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious.