Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Instead, they obtained a stable colloidal suspension. We can send by Fedex, by ship or by plane according to international rules. Avicel PC 611 (FMC Biopolymer) . Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Fiber supplements can lessen the absorption of some . 1.3. BIOACCUMULATIVE POTENTIAL IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . . The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. High performance lubricant that brings more to the tablet. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? CAS #: 9004-34-6 1.6. Millipore. Report Category. The short-term limit for total inhalable dust is 20 mg/m3. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. Cellulose microcrystalline for column chromatography. Page 1 of 8. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm 3 0 obj All Rights Reserved. Quick Links. We respect your privacy FMC Privacy Policy. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. CAS 9004-34-6, pH 5 - 7.5. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. An agricultural sciences company. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. PDF (2.77 mb) 2021 FMC Sustainability Report. endobj It is, however, a good source of fibre. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. (1962). Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. Hi, let us know if you have any questions as you visit our website. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Safety Data Sheet for Cellulose microcrystalline 102331. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Origin(s): Plant/Botanical. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. <> 102331. Find answers in our support articles. : 5. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. } !1AQa"q2#BR$3br The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. P}MFbN#[>r(y /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Browse Avicel PH-101 and related products at MilliporeSigma. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . /MediaBox [0 0 612 792] In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. In extrusion-spheronisation, it is the excipient of choice. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Trademarks: Avicel PH-102. 1 0 obj Magazine: Material safety data sheet - FMC Corporation. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Learn about FMC's differentiated biologically-based crop solutions. B;vLZpHU%ChUyD+[ Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Have an order or account question, find answers in our Online Support articles. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. stream FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. 4 0 obj JFIF ` ` ZExif MM * J Q Q Q C The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Regulatory Information The 'Substance identity' section is calculated from substance identification information from all ECHA databases. PharmaCentral 2021 . iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? 4 0 obj Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. The aqueous solution to barrier membrane coating. %PDF-1.4 Microcrystalline Cellulose; Cellulose; Functions. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . The figure below illustrates the structural organisation of cellulose within plants. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. MATERIAL SAFETY DATA SHEET. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER EMCOCEL XLM 90. undefined. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. w !1AQaq"2B #3Rbr These grades have particle sizes ranging from <30 to approximately 200. Product Name: Microcrystalline Cellulose 1.2. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. cas:9032-51-3 msds CELLULOSE PAB. . AVICEL RC 581. %PDF-1.5 on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Molecular weight: Not Applicable 1.5. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream endobj The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026.