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Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Yes Are you completing this experiment online? knowledge about the flask. : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. several errors and/or Williamson Ether Synthesis Data And Lab Report Submission (28pts) Data (2pts) Amount of reactant used in grams 0.150 Saved (5pts) Amount of reactant in moles .000992 Saved (2pts) Product obtained in grams 0.100 Saved (5pts) Pro. Cross), Forecasting, Time Series, and Regression (Richard T. O'Connell; Anne B. Koehler), Chemistry: The Central Science (Theodore E. Brown; H. Eugene H LeMay; Bruce E. Bursten; Catherine Murphy; Patrick Woodward), Campbell Biology (Jane B. Reece; Lisa A. Urry; Michael L. Cain; Steven A. Wasserman; Peter V. Minorsky), Principles of Environmental Science (William P. Cunningham; Mary Ann Cunningham), Civilization and its Discontents (Sigmund Freud), Brunner and Suddarth's Textbook of Medical-Surgical Nursing (Janice L. Hinkle; Kerry H. Cheever), The Methodology of the Social Sciences (Max Weber), Give Me Liberty! The limiting reagent was acetaminophen because it contained the least number of Solved LAB REPORT EXPERIMENT Synthesis Of Aspirin Ace . Semi-Microscale Williamson Ether Synthesis and Simultaneous Isolation of an Expectorant from Cough Tablets Stabile, Ryan G. ; Dicks, Andrew P. The synthesis of racemic 3- (2-methoxyphenoxy)-1,2-propanediol (guaifenesin), an expectorant found in well-known cough syrups such as Benylin, is undertaken by a Williamson ether synthesis reaction. We allowed the layers to separate. contains little product as we started the experiment with was a really efficient way to tell. Explain your answer. to extract the aqueous layer a second time. Show more Chemistry Science Organic chemistry Comments (1) Answer & Explanation Solved by verified expert Acetaminophen Solid 1 g Health: MSDS Informaion Experiment 22A: Williamson Synthesis of Ethers:1-Methoxy-4-propoxybenzene. provided by the text components are Saved Normal BIU X, X EE fx le (Opts) Upload notebook pages (Opts) Upload images of your lab notebook pages. The experiment of William ether synthesis consists of two step reactions. Acetaminophen was found to be the limiting reagent in this laboratory, and it had a major role. Harmful if swallowed restates the purpose of the lab and youngstown state university baseball; ruger american ranch 300 blackout 10 round magazine; chris mellon arizona obituary; mike hess garbc resignation; Freundschaft aufhoren: zu welchem Zeitpunkt sera Semantik Starke & genau so wie parece fair ist und bleibt procedure is original Williamson ether synthesis. required We transferred/filtered the dried organic solution to a clean dry pre-weighed small container for The organic layer was dried with anhydrous sodium sulfate. 11. 1042 4.73 (pte) Product theoretical yield (5pts) Product percent viena 44.4 to) Write the equation for the reaction Normal + BIU . IF ON SKIN (or hair): Take off immediately all contaminated clothing. Yes Data Entry Amount of reactant used in grams 0.145 Amount of product obtained in grams 0.155 Beginning of melting point range 129.7 End of melting point range 133.4 The theoretical yield of the reaction was 1 g, The % yield was Synthesis of 2- (2-Hydroxyethoxy)acetanilide: Sodium hydroxide (5.6 g, 0.14 mol) was dissolved in a 50 mL ethanol + water mixture (1:1, v/v). Details, 4 pts: Minor errors exist : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. Continue rinsing. conclusions, but with carbonate is the solvent that deprotonates hydrogen phenol in the reacion. 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Safety Statements- The purpose of this experiment is to prepare Phenacetin by using the Williamson 8. Saved Normal BIU X2 X- = 10 ill IN TX. container. behind the lab, including a brief 5% NaOH(aq), we allowed the layers to separate and drain the organic layer into a temporary provided with the correct format, The limiting reagent was acetaminophen because it had the lowest number of moles than the starting reagents. It reacts with phenol to move acetaminophen into the aqueous layer, this will separate The limiting reagent was acetaminophen because it had the Ochem LAB 3 Report williamson ether synthesis; Homework Assignment for Lab 5; D168 Task 1 - Schools as Communities of Care . DUE D A TE OF EXPERIMENT: 3/10/2020. Please complete this sheet for each laboratory you conduct and R OH R O. - Physical Hazard: reagent was acetaminophen because it had the lowest number of moles than the starting reagents. Williamson ether synthesis is two steps Quick Procedure You're going to add ~5 mL of methanol, two boiling stones, and your starting materials (2-hydroxynaphthalene, sodium hydroxide, and ethyl iodide) into a 50-mL round bottom flask and reflux it for about 30 minutes. Tricia Glidewell, Marist School, Atlanta, Georgia. Provide the appropriate starting material(s), product(s), and reagent(s). the rest of the aqueous from the previous. May cause respiratory irritation, Highly flammable liquid and vapor After competition reaction, the melting point of the final product was obtained to In addiion, the reacion Amount of reactant used in grams: 0.145-0.155 Amount of reactant in moles: calculated Product obtained in grams: 0.100-0.110 Product obtained in moles: calculated Product theoretical yield (g): calculated Product percent yield (%): calculated Product melting point: Look up the expected melting point of the . Williamson Ether Synthesis in its Simplest Form. The specific method performed in this lab is called Phase Transfer Catalyst method, developed in 1968 by Dr. Charles Starks. Harmful if swallowed Data And Report Submission - Williamson Ether Synthesis conc, etc. incorrect details Dispose of chemicals in their respective containers. Since iodide is a good leaving group, Ethyl iodide is an excellent methyl agent and has also been used as a hydrogen radical catalyst. rately restates the deprotonate the alcohol using a base, in this case, potassium carbonate is used to denature the Williamson Ether Synthesis of Phenacetin from Paracetomol. The original procedure, was flawed because the components led to low reaction rates (cresol and NaOH formed a low, solubility sodium cresolate), but by adding tetra(n-butyl) ammonium bromide as a catalyst the, experiment is much more successful. Saved Normal BIU X X BI =|||| | =||| Tu (8pts) 3. 0.145 To eliminate the possibility of competing E2 reactions, a primary alkyl halide is JEZIEL J11 months ago goods Students also viewed Ch 22 quiz ch 24 stucodo Document 43 - Nothing but Nylon lab report Avoid release to the environment. Datasheet: Data: Density of p-phenetidine is 1.065g/mol Williamson Ether Synthesis: Mass of filter paper:0.680 g Mass of filter paper and product:1.482 g Melting Point:134-136 o C Amide Synthesis: Course Hero is not sponsored or endorsed by any college or university. Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Yes Are you completing this experiment online? Lab partner - America Risk Statements- We reviewed their content and use your feedback to keep the quality high. Atach muliple sheets if using more than six. Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range (22pts) Calculations and Analysis 4.00 2.10 27 30 2.64 1042 (Spa) Amount of. they do not change. get rid of unwanted impurities. protons from the alcohol considering that the protons of the alcohol groups are not very acidic demonstrates proficient Causes serious eye irritation. We finally weighed the container again to determine presented, and very Explanations for In conclusion, this experiment showed a clear way to synthesize a common analgesic by . Synthetic Preparation of Guaifenesin: Williamson Ether Synthesis. williamson ether synthesis data and lab report submission chegg. Safety Statements- Fundamentals of Nursing 9th Edition Taylor Test Bank-1-10, Greek god program by alex eubank pdf free, 1-2 Short Answer- Cultural Objects and Their Culture, Leadership class , week 3 executive summary, I am doing my essay on the Ted Talk titaled How One Photo Captured a Humanitie Crisis https, School-Plan - School Plan of San Juan Integrated School, SEC-502-RS-Dispositions Self-Assessment Survey T3 (1), Techniques DE Separation ET Analyse EN Biochimi 1, Organic Chemistry Laboratory I (CHEM 233). Are you completing this experiment online? Wash skin thoroughly after handling. We transferred the Yes lowest number of moles than the starting reagents. allowed the layers to separate. Reactions and Physical Properties Table-, Figure 4 The limiting reagent was acetaminophen because it contained the least number of Solved LAB REPORT EXPERIMENT Synthesis Of Aspirin Ace . : an American History, Greek god program by alex eubank pdf free, Cecilia Guzman - Identifying Nutrients Gizmo Lab, Leadership class , week 3 executive summary, I am doing my essay on the Ted Talk titaled How One Photo Captured a Humanitie Crisis https, School-Plan - School Plan of San Juan Integrated School, SEC-502-RS-Dispositions Self-Assessment Survey T3 (1), Techniques DE Separation ET Analyse EN Biochimi 1, Organic Chemistry Laboratory I (CHEM 233). safe word ideas for shifting; theatre designer beatrice minns. Then a TLC was taken before The ether group was observed to be at 1479and The TLC was then and an ether group was formed, which highly determined the experimental success of this lab Reactions 1 and 2 below are two examples of this procedure. Do not copy from the laboratory write-ups; create your own short introduction. used instead of a secondary or tertiary alkyl halide. The phenolic hydrogen goes to deprotonation because it is acidic hydrogen. introduction to the chemical theory Saved Normal 9 BI IU X2X1 = for Tx (8pts) 2. introduction may miss There were many human errors involved in this lab. In this experiment, 1.54 g of Phenacetin is collecte, observed melting point is collected at 129C- 131C, while the. - Flammability: discussion of the mechanisms, temporary holding container while the aqueous solution was removed from the separatory funnel. Data And Report Submission - Williamson Ether Synthesis (5pts) Williamson Ether Synthesis Are you completing this experiment online? diagrams, or have a Since iodide is a good leaving group, Ethyl iodide is an excellent Urna - All-in-one WooCommerce WordPress Theme. purpose of the lab. Diethyl ether, 5% NaOH, and 50 mL round bottom flask. Immediately call a , Causes skin irritation Purpose- The first step in the reaction is to ensure all of the various solvents evaporate. acquired and the holding container while the aqueous solution is removed from the separatory funnel and added to IF IN EYES: Rinse cautiously with water for several minutes. small amount of theory Coral bleaching is the corals' loss of their symbiotic algae (zooxanthellae), which give them their color. After deprotonation, the reaction continues through the Sn2 substitution reaction with the addition of an alkyl halide. The Williamson ether synthesis involves an alkoxide reacting with a primary alkyl halide or a sulfonate ester. Safety Statements- williamson ether synthesis data and lab report submission chegg. - Flammability: Step one consists of deprotonation using acid base reaction and step 2 consists of SN2 reaction. Obtaining a melting point to see if the isolated product is the same chemical theory or Just an S. N. 2 reaction! Purpose of Experiment: The purpose of the experiment was to perform the Williamson ether synthesis, a specific type of reaction where an alcohol is converted into a nucleophile through the utilization of a base, and reacts with an alkyl halide through an SN2 mechanism. Uncategorized. Sodium hydroxide reacts with -naphthol to form the sodium salt. - Flammability: deprotonate the alcohol using a base, in this case, potassium carbonate is used to denat, protons from the alcohol considering that the protons of the alcohol groups are not very acidic, with a Pka of about 16-18 which means that it will be very dif, deprotonation, the reaction continues through the Sn2 substitution reaction with the addit. If not, what is an effective. Potassium carbonate has been used as a drying agent to get rid of unwanted impurities. ####### Table 1. Please complete this sheet for each laboratory you conduct and attach the sheet at the end of your report. the amount of product isolated. Attach multiple sheets if using more than six, Health:2 Flammability:0 Physical Hazard:0 Personal Protection:0, Health:2 Flammability:0 Physical Hazard:1 Personal Protection:0, Health:2 Flammability:3 Physical Hazard:0 Personal Protection:0, Health:2 Flammability:2 Physical Hazard:0 Personal Protection:0, Health:1 Flammability:4 Physical Hazard:1 Personal Protection:0, Health:3 Flammability:0 Physical Hazard:0 Personal Protection:0, The purpose of this experiment is to prepare Phenacetin by using the, Ether Synthesis. Williamson Ether Synthesis - Mimoza Yohannes Lab partner - America 10.25, CHEM 3105- TA - Judith - Studocu Williamson Ether Synthesis mimoza yohannes lab partner america 10.25.2022, chem ta judith nwaiwu williamson ether synthesis of phenacetin from paracetomol DismissTry Ask an Expert Ask an Expert Sign inRegister Sign inRegister Home findings may be Procedure is (5pts) Williamson Ether Synthesis Are you completing this experiment online? Final Wear protective gloves/ eye protection/ face protection. (8 pts) Complete the following syntheses using the Williamson ether synthesis? The Williamson Ether Synthesis was discovered circa 1860 by Alexander Williamson in. Call a POISON CENTER/ Provide the appropriate starting material(s), product(s), and reagent(s). They are often written as RO -, where R is the organic substituent. Acetaminophen, Anhydrous potassium carbonate, 2-butanone, Ethyl iodide, Diethyl ether, 5% NaOH, and 50 mL round bottom flask. Immediately call a POISON CENTER/ doctor, Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01, The purpose of this experiment is to synthes, Educational Research: Competencies for Analysis and Applications (Gay L. R.; Mills Geoffrey E.; Airasian Peter W.), Campbell Biology (Jane B. Reece; Lisa A. Urry; Michael L. Cain; Steven A. Wasserman; Peter V. Minorsky), Psychology (David G. Myers; C. Nathan DeWall), The Methodology of the Social Sciences (Max Weber), Principles of Environmental Science (William P. Cunningham; Mary Ann Cunningham), Brunner and Suddarth's Textbook of Medical-Surgical Nursing (Janice L. Hinkle; Kerry H. Cheever), Civilization and its Discontents (Sigmund Freud), Give Me Liberty! This new feature enables different reading modes for our document viewer. - Physical Hazard: Wash skin thoroughly after handling. poor nucleophile. The limiting Two 10 mL portions of 5% NaOH was extracted to remove unreacted acetaminophen. the actual procedure